Parkinson's disease motor subtypes and mood.
Identifieur interne : 000C69 ( Main/Exploration ); précédent : 000C68; suivant : 000C70Parkinson's disease motor subtypes and mood.
Auteurs : David J. Burn [Royaume-Uni] ; Sabine Landau ; John V. Hindle ; Michael Samuel ; Kenneth C. Wilson ; Catherine S. Hurt ; Richard G. BrownSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Disability Evaluation, Female, Freezing Reaction, Cataleptic (physiology), Humans, Male, Middle Aged, Mood Disorders (classification), Mood Disorders (etiology), Motor Activity (physiology), Parkinson Disease (complications), Predictive Value of Tests, Psychiatric Status Rating Scales, Sensation Disorders (etiology).
- MESH :
- classification : Mood Disorders.
- complications : Parkinson Disease.
- etiology : Mood Disorders, Sensation Disorders.
- physiology : Freezing Reaction, Cataleptic, Motor Activity.
- Adult, Age Factors, Aged, Aged, 80 and over, Disability Evaluation, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales.
Abstract
Parkinson's disease is heterogeneous, both in terms of motor symptoms and mood. Identifying associations between phenotypic variants of motor and mood subtypes may provide clues to understand mechanisms underlying mood disorder and symptoms in Parkinson's disease. A total of 513 patients were assessed using the Hospital Anxiety and Depression Scale, and separately classified into anxious, depressed, and anxious-depressed mood classes based on latent class analysis of a semistructured interview. Motor subtypes assessed related to age-of-onset, rate of progression, presence of motor fluctuations, lateralization of motor symptoms, tremor dominance, and the presence of postural instability and gait symptoms and falls. The directions of observed associations tended to support previous findings with the exception of lateralization of symptoms, for which there were no consistent or significant results. Regression models examining a range of motor subtypes together indicated increased risk of anxiety in patients with younger age-of-onset and motor fluctuations. In contrast, depression was most strongly related to axial motor symptoms. Different risk factors were observed for depressed patients with and without anxiety, suggesting heterogeneity within Parkinson's disease depression. Such association data may suggest possible underlying common risk factors for motor subtype and mood. Combined with convergent evidence from other sources, possible mechanisms may include cholinergic system damage and white matter changes contributing to non-anxious depression in Parkinson's disease, while situational factors related to threat and unpredictability may contribute to the exacerbation and maintenance of anxiety in susceptible individuals.
DOI: 10.1002/mds.24041
PubMed: 22162098
Affiliations:
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Le document en format XML
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Hindle</name></author><author><name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name></author><author><name sortKey="Wilson, Kenneth C" sort="Wilson, Kenneth C" uniqKey="Wilson K" first="Kenneth C" last="Wilson">Kenneth C. Wilson</name></author><author><name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S" last="Hurt">Catherine S. Hurt</name></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G" last="Brown">Richard G. Brown</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24041</idno><idno type="RBID">pubmed:22162098</idno><idno type="pmid">22162098</idno><idno type="wicri:Area/PubMed/Corpus">000F38</idno><idno type="wicri:Area/PubMed/Curation">000F38</idno><idno type="wicri:Area/PubMed/Checkpoint">000C95</idno><idno type="wicri:Area/Ncbi/Merge">003492</idno><idno type="wicri:Area/Ncbi/Curation">003492</idno><idno type="wicri:Area/Ncbi/Checkpoint">003492</idno><idno type="wicri:Area/Main/Merge">000C85</idno><idno type="wicri:Area/Main/Curation">000C69</idno><idno type="wicri:Area/Main/Exploration">000C69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease motor subtypes and mood.</title><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name></author><author><name sortKey="Hindle, John V" sort="Hindle, John V" uniqKey="Hindle J" first="John V" last="Hindle">John V. Hindle</name></author><author><name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name></author><author><name sortKey="Wilson, Kenneth C" sort="Wilson, Kenneth C" uniqKey="Wilson K" first="Kenneth C" last="Wilson">Kenneth C. Wilson</name></author><author><name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S" last="Hurt">Catherine S. Hurt</name></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G" last="Brown">Richard G. Brown</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Female</term><term>Freezing Reaction, Cataleptic (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (classification)</term><term>Mood Disorders (etiology)</term><term>Motor Activity (physiology)</term><term>Parkinson Disease (complications)</term><term>Predictive Value of Tests</term><term>Psychiatric Status Rating Scales</term><term>Sensation Disorders (etiology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Freezing Reaction, Cataleptic</term><term>Motor Activity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is heterogeneous, both in terms of motor symptoms and mood. Identifying associations between phenotypic variants of motor and mood subtypes may provide clues to understand mechanisms underlying mood disorder and symptoms in Parkinson's disease. A total of 513 patients were assessed using the Hospital Anxiety and Depression Scale, and separately classified into anxious, depressed, and anxious-depressed mood classes based on latent class analysis of a semistructured interview. Motor subtypes assessed related to age-of-onset, rate of progression, presence of motor fluctuations, lateralization of motor symptoms, tremor dominance, and the presence of postural instability and gait symptoms and falls. The directions of observed associations tended to support previous findings with the exception of lateralization of symptoms, for which there were no consistent or significant results. Regression models examining a range of motor subtypes together indicated increased risk of anxiety in patients with younger age-of-onset and motor fluctuations. In contrast, depression was most strongly related to axial motor symptoms. Different risk factors were observed for depressed patients with and without anxiety, suggesting heterogeneity within Parkinson's disease depression. Such association data may suggest possible underlying common risk factors for motor subtype and mood. Combined with convergent evidence from other sources, possible mechanisms may include cholinergic system damage and white matter changes contributing to non-anxious depression in Parkinson's disease, while situational factors related to threat and unpredictability may contribute to the exacerbation and maintenance of anxiety in susceptible individuals.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G" last="Brown">Richard G. Brown</name><name sortKey="Hindle, John V" sort="Hindle, John V" uniqKey="Hindle J" first="John V" last="Hindle">John V. Hindle</name><name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S" last="Hurt">Catherine S. Hurt</name><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name><name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name><name sortKey="Wilson, Kenneth C" sort="Wilson, Kenneth C" uniqKey="Wilson K" first="Kenneth C" last="Wilson">Kenneth C. Wilson</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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